Research Selected Works Talks Contact

Rongxin Zhang

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The greatest truths are the simplest. —— 大道至简

Introduction

Hi, I'm Rongxin, and welcome!
I am currently a postdoctoral researcher at the Feinberg School of Medicine, Northwestern University. Prior to this, I received my Ph.D. from the State Key Laboratory of Digital Medical Engineering at Southeast University, during which I did part of my Ph.D. training in Dr. Jean-Louis Mergny's lab at École Polytechnique in France.
My Ph.D. projects involved uncovering the regulatory role of G-quadruplexes (G4s), special non-B nucleic acid secondary structures, and their implication in diseases.

Research Overview
Figure adapted from my Ph.D. dissertation.

Moving forward, and with the goal of unlocking the secrets hidden within the "Book of Heaven" (the human genome), my research interests lie in the analysis and interpretation of large-scale human multi-omics data through bioinformatics approaches. More specifically, I aim to understand and elucidate the regulatory mechanisms of the human genome—for example, the impact of sequence variants and chromatin-level regulatory features on genome function—and how their dysregulation contributes to the development and progression of human diseases, such as cancer. In addition, I am passionate about applying machine learning methods to model and address unresolved challenges in biology and medicine.

Education

Ph.D. in Bioinformatics

2018 – 2024

Southeast University, Nanjing, CHINA
Advisor: Xiao Sun

Visiting Ph.D.

2022 – 2023

École Polytechnique, Palaiseau, FRANCE
Advisor: Jean-Louis Mergny

B.S. in Bioinformatics

2014 – 2018

Nanjing Medical University, Nanjing, CHINA
Advisor: Qianghu Wang

Selected Works

G-quadruplexes as pivotal components of cis-regulatory elements in the human genome Paper
BMC Biology, 2024
View Paper
G-quadruplex structures are key modulators of somatic structural variants in cancers Paper
Cancer Research, 2023
View Paper
Whole Genome Identification of Potential G-Quadruplexes and Analysis of the G-Quadruplex Binding Domain for SARS-CoV-2 Paper
Frontiers in Genetics, 2020
View Paper
Biological Data Analysis and Practice Book
Rongxin was responsible for Chapter 9 [Transcription factor binding data and its analysis].
Southeast University Press, 2021
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Talks

Structure Matters: Unraveling G-Quadruplex Influence on Regulatory Elements
The Second Bioinformatics Academic Conference of the Yangtze River Delta 2024
Shanghai, China
Integrative analyses reveal G-quadruplex structure as a key modulator of cancer genome instability
Chinese Association for Artificial Intelligence Young Scholars Forum on Bioinformatics and Artificial Intelligence 2022
Nanjing, China
Genomic distribution and potential role of RNA G-quadruplexes in SARS-CoV-2
The 11th Bioinformatics Conference of Jiangsu Province 2021
Nanjing, China